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WormBook is a comprehensive, open-access collection of original, peer-reviewed chapters covering topics related to the biology of Caenorhabditis elegans and other nematodes. Wormbook also contains: WormMethods, a collection of protocols for nematode researchers; WormHistory, personal perspectives on C. elegans research; and the Worm Breeder's Gazette, an informal, non-refereed, biannual newsletter for the interchange of ideas and information related to C. elegans and other nematodes.
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C. elegans


News and Notes
April 30 2015
New chapter added to Molecular biology
Operon and non-operon gene clusters in the C. elegans genome, by Thomas Blumenthal, Paul Davis and Alfonso Garrido-Lecca, has been published in the Molecular biology section. This chapter discusses a variety of tight-linkage gene arrangements in the C. elegans genome, summarizes the current knowledge on several variations of operon processing, and describes non-operon gene clusters.
December 30 2014
Chapter on polarity establishment in the embryo updated
Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos, by Lesilee Rose and Pierre Gönczy, has been published in the Developmental control section. This chapter updates Asymmetric cell division and axis formation in the embryo, by the same authors. The updated chapter describes the mechanisms that transform an isotropic system into a polarized one in the first cell cycle, and further discusses how cell signaling in subsequent divisions builds upon the initial polarity to further refine cell fates.
December 23 2014
New chapter added to Cell biology
Membrane ion transport in non-excitable tissues, by Keith Nehrke, has just been published in the Cell biology section. This chapter discusses the roles of calcium and proton signaling, pH, and osmotic balance in aspects of C. elegans behavior and physiology.
December 17 2014
Anthelmintic drug chapter updated
Anthelmintic drugs and nematicides: studies in Caenorhabditis elegans, by Lindy Holden-Dye and Robert Walker, an update of their chapter Anthelmintic drugs, has been added to the Disease models and drug discovery section. The chapter discusses the use of C. elegans as a model 'parasite', and reviews its use in the study of nematode control and as a platform for anthelmintic and nematicide discovery and development.
December 5 2014
DNA repair chapter updated
Replication and repair by Ann Rose has just been added to the Molecular biology section of WormBook. This chapter updates and greatly expands the 2006 chapter DNA repair by Nigel O'Neil and Ann Rose, and focuses on the use of C. elegans in the study of the Fanconi Anemia (FA) repair pathway.
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